The adenine nucleotide translocator in genetically and physiologically modified yeast mitochondria
نویسندگان
چکیده
منابع مشابه
Adenine Nucleotide Translocator Transports Haem Precursors into Mitochondria
Haem is a prosthetic group for haem proteins, which play an essential role in oxygen transport, respiration, signal transduction, and detoxification. In haem biosynthesis, the haem precursor protoporphyrin IX (PP IX) must be accumulated into the mitochondrial matrix across the inner membrane, but its mechanism is largely unclear. Here we show that adenine nucleotide translocator (ANT), the inne...
متن کاملAdenine nucleotide translocator in heart.
The adenine nucleotide translocator (ANT) spans the inner mitochondrial membrane and facilitates exchange of cytosolic ADP for ATP within the mitochondrial matrix. ANT represents the most prominent single protein component of the inner mitochondrial membrane (1). However, its role in cardiac disease processes and physiology has only recently been a major focus of attention. ANT participates in ...
متن کامل[The role of adenine nucleotide translocator in the regulation of oxidative phosphorylation in heart mitochondria].
The regulatory role of adenine nucleotide translocase in oxidative phosphorylation was determined by titration of respiration of isolated rabbit heart mitochondria with carboxyatractyloside in the creatine phosphokinase ADP-regenerating system, which is not rate-limiting. It was found that the respiration rate is not controlled by adenine nucleotide translocase in states 3 and 4. Within the phy...
متن کاملAdenine nucleotide translocator promotes oxidative phosphorylation and mild uncoupling in mitochondria after dexamethasone treatment.
The composition of the mitochondrial inner membrane and uncoupling protein [such as adenine nucleotide translocator (ANT)] contents are the main factors involved in the energy-wasting proton leak. This leak is increased by glucocorticoid treatment under nonphosphorylating conditions. The aim of this study was to investigate mechanisms involved in glucocorticoid-induced proton leak and to evalua...
متن کاملAdenine nucleotide exchange in mitochondria
We have previously described a fluorimetric method to measure ADP-ATP exchange rates in mitochondria of permeabilized cells where phosphorylases, kinases, ion pumps exhibiting substantial ATP hydrolase activity and other competing reactions interconverting adenine nucleotides are present. This was achieved by recording changes in free extramitochondrial [Mg] reported by the Mg-sensitive fluores...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1974
ISSN: 0014-5793
DOI: 10.1016/0014-5793(74)80871-9